Endocrine Abstracts

Developmental exposure to endocrine-disrupting compounds may adversely affect female reproductive physiology. The present study investigated the effect of Pirimiphos-methyl (PM), an organophosphate pesticide, widely used to protect crops and grains against pests, on puberty onset in female rats. Female weanling rats were orally treated with 20 mg/kg and 40 mg/kg of PM for ten consecutive days from postnatal day 22 to 31. Following vagina opening and attainment of estrus and di...